Objective: To investigate the effect of different
dose of
dexamethasone on
thrombosis model of
mice. Methods:
Tail thrombosis was induced by carrageenan. The percentage of thrombosis
length in tail, protime(PT), red blood cell number (RBC), mean cell hemoglobin (MCH), haematocrit (HCT) and platelet count (PLT) were detected. The plasma t PA and PAI activities were detected by chromogennic substrate analysis. Results: Compared with the thrombosis control groupⅠ, the percentage of thrombosis′ length in tail, RBC,MCH,HCT and PAI in the higher dose group were significantly
increased ( P<0 05 or P <0 01). In comparision with the thrombosis control groupⅡ, the percent of thrombosis length in tail decreased, PT lengthened and t PA activity were increased ( P <0 05) . Conclusion: Dexamethasone had double mechanism on the thrombosis. The fact that higher dose of dexamethasone promoted thrombosis mainly was due to the increase of blood viscosity because of increased Hb and RBC and the refrained fibrinolysis system caused by the increase of PAI; The lower dose of dexamethasone had the effect of refraining thrombosis. The mechanism may be associated with the strengthened activity of fibrinolysis system from decreased exogenous coagulation factors and increased t PA.
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