The spatial variability of irrigated desert soil nutrients has been analyzed for Hexi region in Gansu province by using mathematical statistics and geo-statistics methods. The results from mathematical statistics showed that the spatial variability of the tested soil nutrients was sharp; the variance coefficient of available NH~+_4-N was the highest(62\^656%), that of pH was the lowest(1\^284%), that of Phosphorous(P) was the second(47\^369%), and that of organic matter(OM) and available potassium(K) were 13\^208% and 38\^075% respectively. The results from geo-statistics analysis revealed that the nugget-sill ratios of all indices of soil nutrients varied from 0.041 3% to 13.780 1% and they showed that there were strong spatial dependences for soil NH~+_4-N, available P, available K, OM and pH. Among the tested soil nutrients the spatial dependences of NH~+_4-N and pH were the strongest and their nugget-sill ratios were (0\^041 3%) and (0\^097 8%), and the spatial dependence of the available P is weakest and the nugget-sill ratio was (13\^780 1%). The effective range of soil fertilities varied from 176 to 294 meters. The results of Kriging showed that to some extend soil nutrients had spatial dependence and geo-statistics method could be used to analyze the spatial variability of soil nutrients.