To establish a method of the gas chromatography for determination of residue solvent of acetone and
isopropanol in cefotaxime
sodium. The test uses 1-propanol as internal standard preparation and uses OV1701column (50 mm×0.25 mm×0 3 μm). Carrier Gas: nitrogen, flow rate: 1 2 mL/min, rate of diversion: 1 ∶ 60;
Temperature of column (temperature program): temperature of starting point: 45℃, retention time: 3min; rate of the rise of temperature: 20 ℃/min; temperature of end point: 105℃. FID detector at 250 ℃. Injector at 250 ℃. Result: within the range of 30～150μg/mL, the rate of peak area of acetone, isopropanol have a good linear proportion respectively with that of internal standard preparation (Acetone: r =0.999 7; isopropanol: r =0.999 6); rate of recovery: acetone 99.7% RSD=1.9%(n =9); isopropanol: 99.5% RSD=2.0%(n =9). Conclusion: this method is easy to operate with precise results, which establishes a reliable method for the control of residue solvent of
cefotaxime sodium.