Objective To assess the anti-obesity effect of Jianzhi Capsules in
obese rats and its influence to lipid metabolism. Methods The obesity rat
model was induced by high fat
diet, and male SD rats weighed 50-70g were randomly allocated into control group and model group, which were being given normal diet and high fat diet respectively for 8 weeks. After the obese model was made successfully, the obese rats were divided randomly into 5 groups, which were administrated orally with Jianzhi Capsules with 165mg/kg, 250mg/kg, 330mg/kg, Xenical with 60mg/kg and water with 2ml per day for 40 days respectively. In the course of experiment, various useful indicators were detected. Results In the obese rats treated with Jianzhi Capsules, the body weight, the visceral fat weight, the diameter of fatty cell and the level of serum TG and TC all reduced significantly. However, the level of serum HDL did not change markedly. Conclusions The experiment shows that
Jianzhi Capsule can regulate and improve lipid metabolism and has an anti-obesity action in obese rats.