Aim To study the
pharmacokinetics of
m-nifedipine (m-Nif) in Beagle dogs. Methods The Beagle dogs were divided into two groups. m-Nif was intravenously
administered to the Beagle dogs in group 1 at the dose of 0.288 mg·kg -1, and it was orally administered to the Beagle dogs in group 2,3 and 4 at the dose of 1.152, 3.456 and 10.370 mg·kg -1, respectively. m-Nif in
plasma was detected by reversed phase
high performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software. Results When m-Nif was intravenously administered, the plasma concentration-time curve was fit to a two-compartment model and T 1/2β was 117 min. When m-Nif was orally administered, the plasma concentration-time curve was fit to a one-compartment model. T 1/2(K e) and C max were 147 min and 20 μg·L -1; at the low dose of 1.152 mg·kg -1. T 1/2(K e) was 122 min and C max was 36 μg·L -1 at the middle dose of 3.456 mg·kg -1. T 1/2(K e)was 144 min and C max was 69 μg·L -1 at the high dose of 10.37 mg·kg -1, respectively. Conclusion It was showed that the speed of elimination of m-Nif was high in Beagle dogs. The absolute bioavailability of m-Nif given orally was very low.