Objective:To explore the effect of Linglu Jiegu Capsule on fracture healing of osteoporosis in animal models.Methods: Male rats aged 10-month were fed with Retinoic Acid for the production of osteoporotic models, fracture were produced at middle shaft of the right radius 14 days after they were given drugs. Then they were divided randomly into 5 groups: Model group, Jiegudan group, Linglu Jiegu Capsule in high dosage group, Linglu Jiegu Capsule in middle dosage group, Linglu Jiegu Capsule in low dosage group. After the 24th hours of operation they were given medicine. Six rats in each group were killed on the 15th and 30th day after operation to observe the radiographic findings and histological changes of the fractural ends.Results:Radiographic findings and histological changes of the fractural ends in group with Linglu Jiegu Capsule were better than those in Model group. Conclusions: The Linglu Jiegu Capsule has the effect of promoting fracture healing in animal models of osteoporsis.