Objective: To investigate the effect of
ShenShu Capsule on mesangial matrix of mesangial protiferative glomerulonephritis
(MSPGN) in rabbits. Methods:Rabbit model of MSPGN was developed. 48 rabbits were randomly divided into following groups; normal controls (group N), pathologic model group (group M) high-dose
ShenShu Capsule group (group S1), low-dose ShenShu Capsule group(groupS2), catropril group (group C) and Shenshu capsule+catropril group (group SC). 24-hour excretive quantity of urine protein(EQUP), the plasma endothelin(ET) and
calcitonin gene-related peptide(CGRP) were detected by routine method. And then renal pathological changes were evaluated. Results: In comparison groups M, EQUP, ET and area of mesangial matrix in group S1, S2, C and SC were significantly reduced (P<0.05) while CGRP increased (P<0.05), and these changes were most significantl in group SC. Conclusions: ShenShu Capsule and catropril can both reduce the urinary protein, have positive effects on ET and CGRP, and prevent renal pathological injury. The effects will be promoted when they are used together.