Objective To study the effects of
Compound Biejia Formula (CBF) on
HRCT images in the
rat model of
pulmonary fibrosis induced by bleomycin. Methods 54 SD male
rats were involved in this experiment. 45 Rats were given bleomycin by drip via the trachea and 9 rats were given the same dose of normal saline in the same way. After 80 days of the administration, HRCT images were observed in parallel in the two groups of the animals and at the same time, a HRCT pathological comparative study was carried out. Results It was found by HRCT that in the lung of the model rats, there was consolidation, thickened lobular septa and interstitium, lobular deformity, nodular shadows, bronchiovascular abnormality, thickened pleurae, ground glass like opacity, and even honeycomb lung in some animals; pathological slices showed that there was fibroid proliferation and marked fibrosis of the interstitium. CBF could improve HRCT images of the lung in the model rats and reduce pulmonary fibroid change. Conclusion The curative effects of CBF on the rats with pulmonary fibrosis may be related with its influencing the pulmonary structure.
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