AIM: To determine the
parameter of the
cefuroxime,
cefmetazole in dogs' bile, in order to provide the accurate usage of antibiotic for doctors with the theoretical evidences. METHODS: Basing on the stoma in the dogs' common bile duct, the dogs were given intravenous injection with cefuroxime 1 g, cefmetazole 1 g,
respectively; then bile was extracted as samples according to the plan, and finally the amount of cefuroxime, cefmetazole in the dogs' bile by the micro organism was examined and the parameter was gotten by 3P87 software. RESULTS: The main parameters of cefuroxime, cefmetazole, such as the peak
concentrations were (39.8± s 0.5) mg·L -1 , (21.4±0.3) mg·L -1 , and T 1/2 were (69.3±0.7) min, (102.1±1.4) min, respectively. CONCLUSION: From the records of this experiment, the drug concentrations of cefuroxime and cefmetazole in the dogs' bile are lower than those of other cephalosporins. Therefore, they are not the superior recommendations for cholecystitis.