ABSTRACT AIM To study the protective effects of
angelica sinensis polysaccharides (ASP) on the colon injury in immunological
colitis rats and its mechanism. METHODS The
immunological colitis model of rats was produced. ASP was used in-tracolonically once a day for 21 days. The colon mucosa damage index(CMDI) was evaluated. The activity of MPO, SOD and the levels of MDA, NO, IL-2, TNF-α, IL-10, TGF-β in the colon were measured. The levels of NO, IL-2, TNF-α in the plasma were detected. RESULTS ASP (250, 500, 1 000 mg · kg-1) could decrease the elevated extents of CMDI, activity of MPO, the levels of MDA, NO, IL-2, TNF-α while increase the reduced activity of SOD, the levels of TGF-β, IL-10 in the model group in a dose-depended manner. The level of NO in the plasma reduced slightly. CONCLUSION Treatment with ASP intracolon can relieve the inflammation reaction, alleviate the colon injury in immunological colitis rats by its immuno-regulation, the ability to pellate oxgen free radical and repair wound.