AIM To study the effects of Scutellarin on
glutathione peroxidase and
thioredoxin reductase gene expression and
activities in liver, kidney and testis tissues of
rats supplemented with upper limit intake (UL) of Se. METHODS RT PCR and enzyme activities were used to determine
GSH Px and
TR mRNA levels and activities. RESULTS GSH Px and TR mRNA levels and activities were remarkably decreased in livers of rats supplemented with UL Se. Scutellarin significantly increased GSH Px and TR mRNA levels and activities in livers of rats supplemented with UL Se. No significant effects were found in rats treated with only Scutellarin as compared with the control. There were also no significant effects of UL Se on GSH Px and TR mRNA levels and activities in rat kidney and testis. CONCLUSION Scutellarin effectively antagonized the decrease of GSH Px and TR mRNA levels and activities in rat livers due to supplementation with UL. The effect of UL on GSH Px and TR mRNA levels shows tissue specificity.
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