AIM To explore if four new
pyrrole derivatives having Ca 2+ antagonizing activity. METHODS Compound 1: 3,5 dimethyl
4 (4 methyl piperazine 1 carbonyl) 1H pyrrole 2
carboxylic acid ethyl ester; compound 2: 3,5 dimethyl 4 <4 (4 nitro phenyl) piperazine 1 carbonyl> 1H pyrrole 2 carboxylic acid ethyl ester; compound 3: 3,5 dimethyl 4 <4 (3 p tolyl acryloyl) piperazine 1 carbonyl> 1H pyrrole 2 carboxylic acid ethyl ester; compound 4: 4 <4 <3 (2 chloro phenyl) acryloyl> piperazine 1 carbonyl> 3,5 dimethyl 1H pyrrole 2 carboxylic acid ethyl ester. The inhibiory effect of 4 compounds on potential dependent calcium channels(PDC) of rat aorta was determined by 45 Ca transmembrane influx technique. RESULTS 45 Ca transmembrane influx was reduced by four new
pyrrole derivatives. Compounds 1 and 2 appeared strong inhibitory effect on PDC and were better than nifedipine. CONCLUSION Four new pyrrole derivatives possessed Ca 2+ antagonizing activity.