Objective To study the anti acute
rejection effect of ethanol extract of poria cocos wolf (EEPCW) in heart
transplantation
rats.Methods Homologous heart transplanted rats were divided into 4 groups ( n =20 in each group). EEPCW 50?mg·kg -1 ·d -1 , EEPCW 25?mg·kg -1 ·d -1 , CsA 5?mg·kg -1 ·d -1 and olive oil 8?ml·kg -1 ·d -1 were given to different groups. Cardiac allograft survival was observed on 10 of each groups. The pathologic lesion, the contents of IL 2 and IFN γ in peripheral blood, percentage of CD3 +, CD4 +, CD8 + lymphocytes and ratio of CD4 +/CD8 + were determined on another 10 in each groups and 10 normal rats. Results Survival of the donor heart was significantly prolonged and pathologic lesion was relieved, the contents of IL 2 and IFN γ in peripheral blood, percentage of CD3 +, CD4 +, CD8 + lymphocytes and ratio of CD4 +/CD8 + were significantly reduced in EEPCW groups.Conclusion Acute
rejection of heart
transplantation can be effectively suppressed by ethanol extract of poria cocos wolf.