Objective To observe the therapeutic effects of Bajiaoxin in the treatment of experimental cystolith. Methods The mice with experimental cystolith induced with benzene di-methanoic acid orally took Bajiaoxin granula.The calculus was weighed, the rates of growth and occurrence were monitored, and renal tissue was examined histologically. Results On the mice experimental cystolith model, the calculus weight (rates of growth) in the groups of high, mid and low doses of Bajiaoxin was 64.67 mg (144.0%),40.11 mg(85.2%),31.44 mg(16.8%) respectively,significantly lower than in the control group ( P <0.05, P <0.01). The calculus occurrence in the normal control group, calculus control group, and Bajiaoxin-treated groups of high, mid and low doses was 0, 67% , 11% , 0, 0 ( X2 = 17. 557, P<0.001).The calculus weight in the Bajiaoxin-treated groups was apparently lower than in the calculus control group ( P < 0.01) . Conclusion The Bajiaoxin granula has obvious therapeutic effects on the experimental cystolith.