Objectives To study the protective effects of Vitamin C on
intestinal mucosal barrier of the scalded rats.Methods The scalded
rats′ model was used.The rats were randomly divided into four groups, scald group, sham-scald group, Vitamin C treatment group, and placebo treatment group.The bacterial translocation, the level of plasma endotoxin and the amount of tissue superoxide dismutase(SOD) were detected in above groups.Results The bacteria in gut translocated into livers, spleens and mesenteric lymphatic nodes after thermal injury.Moreover, the number of bacteria colonized in those organs were very larger.However, Vitamin C could obviously inhibit bacterial translocation from the gut.There was significant difference between the scald group and Vitamin C treatment group (P<0.05). Furthermore, Vitamin C could also decrease the level of plasma endotoxin and reduce the consumption of SOD in livers, guts and serum (P<0.01 vs scald group).Conclusion Vitamin C had a protective function for
intestinal mucosal barrier of the scalded rats.