Objective To study the effect of ligustrazini (LGT) on
myocardial cell
energy metabolism during myocardial ischemia-reperfusion
injury (MIRI).Methods Using rabbit MIRI models,animals were randomly divided into three groups (n=10 in each),control group(A),MIRI group(B) and MIRI+LGT group(C),the contents of ATP,ADP and AMP (TAN,EC) in the
myocardial tissue were measured,respectively.Meanwhile,the ultrastructure changes in myocardium were observed during MIRI.Results In C group ATP,ADP,TAN and EC levels of myocardial tissue were higher than those in B group(ATP:C(5 05±1 34) μmol/g(wet·weight),B(2 86±1 22) μmol/g(wet·weight),P<0 01;ADP:C 1 67±0 40,B 1 12±0 25,P<0 01;TAN:C 8 42±1 90,B 5 83±1 55,P<0 01;EC:C 0 70±0 03,B 0 58±0 07,P<0 01);and there were not significant differences between C and A group about ADP?AMP and TNA (ADP:A(2 04±0 53) μmol/g(wet·weight),P>0 05;AMP:A(1 45±0 29) μmol/g(wet·weight),P>0 05;TAN:A(10 26±2 05) μmol/g(wet·wt),P>0 05);abnormal changes of myocardial ultrastructure in B group were ameliorated remarkably during MIRI.Conclusions LGT could improve myocardial cell
energy metabolism in the reperfusion injury after myocardial ischemia.