Objective:To evaluate the efficacy of ambroxol(mucosolvan) and its effect on the transport of sulperazon(cefoperazone/sulbactam) into pulmonary.Methods:The randomized,open parallel controlled trial was carried out in 106 old patients with pneumonia.They were divided into test group( n =54) and control group( n =52).The test group received intravenous drip of sulperazon 3.0g dissolved in 100mL normol saline at the speed of 30mg·min -1 ,twice a day,while dripping half,added 45mg ambroxol intravenous injection,the time of which was not less than 5 minutes.The control group received the same treatment except using ambroxol.Results:The effective rate and cure rate of the test group was 87.04%( P <0.05) and 70.37%( P <0.01),while those of the control group was 78.80% and 57.24%.The bacteria clearance rate of the test group and the control group was 78.17% and 68.18% ( P <0.05).Drug concentration in expectoration of the test group was higher than that of the control group( P <0.01);but no difference was found between the serum drug concentration of the 2 groups.Conclusion:Ambroxol not only prompts expectoration,but also facillitates sulperazon's transport into pulmonarty,and increase its bactericidal action.