Objective:To investigate the effects of
Litchi seed water extractant(LS)on insulin
sensitivity in type 2 diabetic rats with
insulin-resistance (IR) and the primary pharmacological mechanism.Methods:The model for type 2 diabetic-insulin-resistant rats (T2DIRR) were performed through intraperitonea injection of lower dosage of streptozocin(30mg·kg -1) and high caloric diet (abounded with sugar & fat),the effects of LS on blood and/or serum contents of glucose,lipids,insulin and insulin sensitive index(ISI) were observed in the model rats.Results:LS lowered significantly fasting blood glucose (FBG) and 2-hours blood glucose (2hBG) after oral glucose tolerance test (OGTT) (P<0.05) and improved impaired glucose tolerance (IGT);decreased markedly the levels of total cholesterols (TC) and triglyceride (TG) (P<0.01),and increased the content of high-density lipoprotein cholesterol (HDL-C) and ratio of HDL-C/TC (P<0.01);and reduced the concentration of insulin in hyperinsulinemia,and potentiated ISI (P<0.01) in T2DIRR.Any noxious and side effects didn't occur in the experiment.Conclusion:In the experiment with type 2 diabetic-insulin-resistant rats,LS can reduce level of blood glucose,regulate components and content of blood lipids,and improve insulin
sensitivity.