Purpose:The aim is to compare the
pharmacological e ff ects of
Cerebrolysin, Naoduotai (Cerebral polypeptide) injection(NDT)
and Naozuz hi(Cerebral tis sue) injection (NZZ).Methods:Acute cerebral ischemia was produced by beheadne ss and by close normobaric hypoxia in mice, acute cerebral ischemia was produced by ligating both bilateral carotid arteries and pneumogastric nerves in mice, a nd it was produced by ligating bilateral carotid arteries in rats.Hypomnesia was p roduced by exposure to ig ethanol or sc NaNO 2 or ip myoscine methabromide.Results:
Cerebrolysin,NDT and NZZ markedly delayed the death time of mice that had beheadness,and ligating both bilateral carotid arteries and pneumogast ric nerves.Cerebrolysin, NDT and NZZ markedly inhibited the exponent and water w e ight of brain and the change of CPK and LDH in serum in rats that had ligating b ilateral carotid arteries,it inhibited the oxygen carrying capacity of blood pas sing through the blood vessel.Cerebrolysin,NDT and NZZ markedly inhibited error times and error delitescence by exposure to ig ethanol or sc NaNO 2 or ip myosc ine methabromide in mice.Conclusion:The
pharmacological effects of t he cerebrolysin and pharmacological effects of the NDT and NZZ were similar.