Objective To study the efficacy of botulinum A toxin injection for the treatment of hemifacial spasm, blepharospasm, Meige′s
syndrome and spasmodic
torticollis. Methods A total of 64 patients, (51 patients with hemifacial spasm, 10 with blepharospasm, 1
Meige′s syndrome and 2 with spasmodic torticollis) were evaluated on therapeutic efficacy of multifocal facial injection. Results Of the 51 patients with hemifacial spasm, 20(40%) patients were completely relieved, 30(59%) remarkable relieved, and one didn′t have improvement; of 10 patients with blepharospasm 4 were remarkably relieved, and 1 had no improvement; one patient with Meige′s syndrome was partial relieved, of the 2 patients with spasmodic torticollis 1 remarkably relieved, the other partial relieved; 97% of the patients experienced relief from spasm. Clinical observation showed marked improvement in symptoms from a few hours to the third day after injection and lasted about 3 to 7 months. The local side effects were transient and mild, no systemic adverse and allergic reactions were noted. Conclusion Botulinum A toxin local injection may control hyperdystonia effectively, and ameliorate patients′ abnormal face contour and posture.