Objective To study the distributive state of adriamycin contents in
targeting tissues of the animals in vivo when the Adriamycin
Magnetic Albumin Microspheres(ADM MAMs) were administrated through the digestive canal and vein.Methods 100 rats were divided into 4 groups,group A(targeting group of
administering through alimentary),group B(non targeting group of administering through alimentary),group C(targeting group of administering via vein),group D(non targeting group of administering via vein),24 rats in each group,The
adriamycin concentration of tissues in the gastric wall、liver and portal vein in each group were measured by fluorophotometry.Results The ADM concentrations in gastric wall、liver tissue and portal vein in the targeting groups were significantly higher than that in non targeting groups( P <0.01),and lasted much more longer( P <0.01).Conclusion After targeting administration of ADM MAMs combination with the external magnetic fields,the drug concentration of the targeting tissue in gastric wall,liver and portal vein may last in high level for a long time,which provide the experimental evidence for the preventing and treating against the gastric cancers and their liver metastasis.