OBJECTIVE To study the antibacterial effects in vitro and protective effects in vivo of Roxithromycin dry suspension.METHODS
To determinate MIC, MBC and ED 50 . RESULTS
Roxithromycin had obvious bacteriostasis on multiple gramnegative bacteria. The MIC 50 of Roxithromycin against
staphylococcus aureus, streptococcus, staphylococcus epidermidis and hemophilus influenzae were 0.78, 0.78, 1.56 and 1.56 mg/L, respectively. The MIC 90 against those bacterias were 6.25, 12.50, 6.25 and 12.50mg/L, respectively. In addition, the ED 50 of Roxithromycin and Lulide dry suspension against staphylococcus aureus was 116.9? mg/kg and 109.8?mg/kg, and the ED 50 of the two drugs against hemophilus influenzae were 55.7?mg/kg and 51.9?mg/kg, respectively . CONCLUSION The experimental results of antibacterial effects in vitro and protective effects in vivo between the Roxithromycin dry suspension and imported Roxithromycin and Lulide dry suspension have no significant difference.