rats were made into the MsPGN model by injection of Thy1.1 monoclonal anti body and randomly divided into three groups,
the treatment group (treated by
Decoction of BuShenHuoXueXieZhuo), the control group and normal group. 24 hour urinary protein contents and hematuria were determined every week, while blood urea nitrogen (BUN), albumin (ALB) and creatinine (CRE) were detected at week 2, 5, and 8. The blood rheology was tested by the end of experiment. At the same time, the pathological changes of MsPGN were also observed through light, immunofluorescent and electronic microscopy. Results: the MsPGN rats showed serious proteinuria, hematuria, abnormal blood rheology and various indexes change in blood biochemistry, but these indexes in the treatment group got markedly improved compared with those of the control group( P<0.05～P <0.01). The light, electronic and immunofluoresent microscopic examination all showed that the pathologic changes in treatment group were less than that of the control. The results showed the Decoction of BuShenHuoXueXieZhuo could markedly protect
renal function, alleviate blood hypercoagulability and delay the progression of glomerular fibriosis and sclerosis.