The properties of toxicokinetics and toxicodynamics showed the rapid rate and much extent of
absorption through
skin and inhalation,the later was main absorption route and half clean speed was longer.The main metabolite of EE is 2 ethoxyacetic acid(EAA),it is a terminal toxicant caused reproductive/developmental toxicity.Physiological materials (such as glycine etc)might be selectively competed with EAA and interrupted the synthesis of one carbon unit,because their chemical structure is similar.These responses mainly occurred in the cells,tissues and systems of active metabolism,e.g.sex glands,blood and born and nerves and so on.This review on
toxicology and occupational hygiene criterion of EE will provide scientific basis for safety evaluation,health risk assessment and establishment of hygiene criterion for 2
ethoxyethanol at the air of workplace and its biological exposure indxes(BEI)of China.