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Shvoong Home>Medicine & Health>m -CHLOROPHENYLPIPERAZINE-INDUCED ANXIETY MODEL IN LIGHT-DARK BOX IN DDY MICEA NEW ECONOMIC AND Review

m -CHLOROPHENYLPIPERAZINE-INDUCED ANXIETY MODEL IN LIGHT-DARK BOX IN DDY MICEA NEW ECONOMIC AND

Article Review   by:TsingHua     Original Author: ACTA PHARMACEUTICA SINICA
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AIM To develop a new economic and simple anxiety model that mimics clinical conditions for screening and studying anxiolytic agents. METHODS The behavior activity of ddy and ICR mice in light-dark box was observed after sc m-chlorophenylpiperazine( m CPP) to induce anxiety. RESULTS m CPP was shown to significantly decrease the activity of ddy mice in light box after sc 1~4 mg·kg -1 , but the activity in dark box was not significantly changed. No significant difference was found in the light box between the 1 mg·kg -1 and the 4 mg·kg -1 group. m CPP showed little effect on the activity of ICR mice in the light box, but it was shown to significantly decrease the activity in the dark box between 2~10 mg·kg -1 . It is easy to show the anxiolytic effect of diazepam only in a small sample by using ddy mice in this model. CONCLUSION It is easy to get effective result by using only a small sample in the light-dark box after m CPP-induced anxiety in ddy mice. It appears that this model is an economic and simple anxiety model that mimics clinical conditions for screening and studying anxiolytic agents.
Published: August 28, 2000   
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