OBJECTIVE The
solid dispersion method was adopted to enhance the
dissolution rate of
nifedipine (NFDP) which is a poorly water-soluble drug.METHOD Solid
dispersions and physical
mixtures with different proportion of weight of NFDP and
PVP were prepared by using polyvinylpyrrolidone (PVP) as a carrier.The physical states of NFDP were investigated by X-ray powder diffraction analysis and DTA. The dissolution rate of NFDP from solid dispersions and from physical mixtures were also compared.RESULTS The dissolution rate of NFDP-PVP solid dispersions was much faster than that of the physical mixtures, and tended to increase with the increase of the proportion of the carrier. The X-ray power diffraction and DTA showed that the drug in the solid
Dispersion existed in amorphous form, and there were no significant changes for the solid dispersion kept in dry place for six months.CONCLUSION The dissolution rate of NFDP can be improved greatly by solid dispersions with proper ratio of drug and carrier.
More abstracts about the Studies on preparation and dissolution of the solid dispersions of nifedipine-polyvinylpyrrolidone