OBJECTIVE To prepare the controlled-release matrix tablets with ideal properties by quantitatively controlled method.METHODS
Experiments were arranged using
uniform design method.Aspirin controlled-release matrix tablets were prepared.The
tensile strength,fragility,dissolution were determined.The effects of each factor could be acquired according to multivariate regression equations.An optimum experimental condition was chosen according to the stipulated target ranges of responses and their regression equations,and the verification experiment was made using this experimental condition.RESULTS Tableting strength,humidity in granules and granule strength were the leading factors which affect tensile strength,fragility,dissolution percentage of tablets.Verification experiment showed that the observed results were closed to the predicted.CONCLUSION The controlled release tablets with ideal properties could be prepared when leading influencing factors would be quantitatively controlled with the guidance of multivaiate regression equations.