Objective:To study the
pharmacokinetics of doxofylline in 10 healthy Chinese volunteers. Methods:After a single oral dose
of 400 mg oxofylline, the plasma drug levels of the volunteers were measured by HPLC. The plasma concentrationtime data obtained was treated with a nonliner program, and fitted with a suitable curve, then the pharmaceutical parameters were calculated. Results:The concentrationtime curve obtained was fitted to a firstorder, one compartment, open model. The main pharmacokinetic parameters were:K a=(2.41±1.63)/h,K e=(0.64±0.27)/h, t 1/2 =(1.28±0.60)h, AUC=(7.58±5.79)(mg·h)/L,T max =(0.98±0.46)h, C max =(2.10± 1.22) mg/L. Conclusion:After an oral single dose of doxofylline tablet, the
pharmacokinetics appears to be a process of firstorder absorption and elimination. It is rapidly absorbed with a marked individual
variability, and rapidly distributed in the body without a obvious distribution phase, and individual variability in elimination is also exists.