To study the
effect of Minor Bupleurum Decoction (MBD) and its
decomposed preparations, decomposition 1 (DC 1) and decomposition 2 (DC 2) in myocardial protection and immunoregulation on
coxsackie virus B 3 m induced myocarditis in mice. Methods: Murine model of experimental myocarditis caused by coxsackie virus B 3 m was developed in Balb/c mice, and were treated by MBD, DC 1 and DC 2. Natural killer (NK) cell activity,
T lymphocyte subsets and histopathological change of
myocardium were examined at various times after MBD, DC 1 and DC 2 were taken. Results: (1)MBD and DC 2 could increase the NK cell
activity significantly, and also regulate the T lymphocyte subsets, while DC 1 did not have this kind of effect; (2) All MBD, DC 1 and DC 2 could protect myocardium obviously, the effect of MBD is better than those of its decomposed preparations. Conclusion: MBD and DC 2 had bi directional regulation on NK cell activity and T cell subsets, all the 3 groups could obviously protect myocardium.
More abstracts about the Myocardial Protection and Immunoregulation of Minor Bupleurum Decoction and Its Decomposed Preparati