To investigate the weight-reducing effect of
Kintop and its probable mechanism in
obese rats. Methods: Body weight, Lee′s index, total
weight of celiac fat tissue, adipocyte size, blood glucose, blood lipid, expression of
leptin in adipocyte (by ABC method), level of serum leptin (by RIA) of obese
rats were chosen as the indexes to compare the weight-reducing effect of different dosages of Kintop. The administration of Kintop lasted 1 month. Results: Good effect could be obtained by administration of medium dose Kintop (40 mg/100g body weight per day) in simple obese rats. At the same time of
reducing body weight, blood cholesterol and sugar levels also decreased in a certain degree. The adipocyte leptin expression reduced and serum leptin elevated in those rats with body weight reduced effectively by Kintop. Conclusion: Medium dose of Kintop administration for 1 month shows evident weight-reducing effect in simple obese rats, the effect might be related to raising the serum leptin level. Kintop also has the effect in lowering blood cholesterol level, and it could lower the blood sugar in
obesity complicated with hyperglycemia by increasing the dosage appropriately.
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