Objective To assess the therapeutic efficacy of Jingmaiyan powders (JP) on lower limbs with deep venous thrombosis Methods Clinical study:224 cases with lower limbs with deep venous thrombosis were divided into three groups randomly In group Ⅰ(n=100) JP 2030g was taken orally three times a day, in group Ⅱ(n=64) the actipyretic dampnessdispelling and bloodactivating stasisremoving agents was administered orally once a day, combined with oral entericcoated aspirin 0 3g,and in group Ⅲ(n=60) Fufang Danshen injection 20ml, anisodamine 10mg and hylysantinfarctase 0 5 u were infused intravenously once a day with the 15day therapeutic course and 35 days interval before the next therapeutic course,combined with oral entericcoated aspirin 0.3g . Animal experimental study: the experiments of antiinflammation, anticoagulation and the effect on hemorheology in the bloodstasis models were carried out respectively. Results After 90day therapy,the cure rate in group Ⅰ(62%) was significantly higher than that in group Ⅱ and Ⅲ (48.4% and 46.7%,P<0.05) ; Animal experimental results showed that JP had significant functions in antiinflammation, anticoagulation and thrombolysis. Conclusions JP is an effective preparation in treating lower limbs with deep venous thrombosis.