Objective: To evaluate the depression effect of propofol and etomidate on stress response reflected by changes
of plasma glucose and cortisol during
induction of
anesthesia.Methods:Forty adult patients (ASAⅠ～Ⅱ) undergoing elective cholecystectomy were randomly divided into group A(propofol,n=20) and group B (etomidate,n=20).Induction of anesthesia with propofol 2mg/kg in group A and with etomidate 04mg/kg in group B.Fentanyl 2μg/kg and atracurium 0mg/kg were given in two groups.Results:(1)The plasma glucose increased from 459±067mmol/L to 493±063mmol/L in group A(P>005) and from 504±050mmol/L to 567±080mmol/L in group B(P<005).(2)The plasma cortisol decreased from 136±517μg/L to 104±556μg/L in group A(P>005) and from 123±518μg/L to 837±413μg/L in group B(P<005).(3)At 5min after intubation, the blood pressure and heart rate were significantly decreased in group A(P<005),and significantly increased in group B(P<005),which recovered to the preinduction level 10min later. Conclusion:Both propofol and etomidate have depressant effect on stress induced by intubation,but propofol is more effective than etomidate during induction of anesthesia.