AIM: To study the
pharmacokinetics and relative bioavailability of
phenoxymethylpenicillin potassium capsule compared to
the tablet. METHODS: Serum and urine concentrations were measured by microbiological assay in 10 healthy volunteers with random crossover oral dose of 500 mg capsule and tablet. Pharmacokinetic parameters and bioavailabilities of 2 preparations were compared. RESULTS: The serum concentrationtime curves appeared to fit the twocompartment open model. c max were (82±121) and (771±109) mg/L; t max (055±011) and (058±017) h; T 1/2ka (021±009) and (020±006) h; T 1/2β (081±021) and (072±008) h; AUC (951±106) and (950±182) h·mg/L respectively. The urinery recovery rates within 24 h were (3533±745)% and (3780±545)% respectively. CONCLUSION: The differences of the above parameters between the capsule and tablet groups are no statistic significance (P>005). The relative bioavailability of
phenoxymethylpenicillin potassium capsules was (10144±959)%. There is bioequivalence between the 2 preparations.