OBJECTIVE:To study the change of the contents of
Cholecystokini-Octapeptide (Cck-8) in the central and peripheral areas in
juvenile rats with anorexia and the effects of Erbao granule. METHOD:The juvenile rat model with anorexia was constructed by replicating the major causes of anorexia in children and was treated with Erbao granule. The contents of CCK-8 in the
hypothalamus and plasma in rats were detected with RIA.RESULTS:The concentrations of CCK-8 in the hypothalamus and plasma of the model group were (122.57±31.79) pmoL/g and (506.88±113.32) pmoL/g, higher than the normal group (89.15±17.94)pmoL/g ( P <0.05) and (253.76±65.09) pmoL/g ( P <0.05). Their food intake was reduced for more than 3 weeks. In the treatment groups with either high or low dosage, the food intake was increased and the contents of CCK-8 resumed its initial reading. CONCLUSION:The concentrations of CCK-8 in the hypothalamus and plasma of the model rats can be increased and the therapy can significantly inhibit the increase.