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Shvoong Home>Medicine & Health>Effect of testosterone undecanoate on spermatogenesis in four healthy Chinese men Review

Effect of testosterone undecanoate on spermatogenesis in four healthy Chinese men

Article Review   by:TsingHua     Original Author: CHINESE JOURNAL OF ANDROLOGY
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In order to study the effect of Testosterone Undecanoate (TU) on spermatogenesis in normal healthy men and toxic and adverse effects of TU on male body.500 mg TU was given to four healthy men by intramuscular injection monthly until severe oligozoospermia or azoospermia achieved.Follow up was held monthly to identify the feelings of the subjects and changes in semen analysis and serum reproductive hormone levels.Results showed that two men had severe oligozoospermia at the fifth injection,azoospermia began at 3~6 months of injection in three men and persisted up to 3~5 months.The sperm count returned to normal level at 6~9 months from commencing the first injection.No adverse effects were found in the study.There was a parallel changes in FSH,LH,sperm concentration and sperm motility during the follow ups.Authors think that 500 mg TU given by intramuscular injection monthly had no adverse effects on male body in the study period.TU may influence endogenous secretion of FSH and LH to regulate spermatogenesis in men.
Published: June 20, 2000   
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