Objective: To observe the influence of
Baoxin mixture on the
neuroendocrine system in
rats with heart failure and explore the mechanism of preventing and curing heart failure.Methods: Wistar rats were subcutaneously injected isoprenaline and randomly divided into five groups: the normal control group,the model group,the high and low
dosage of Baoxin
Mixture group and the
digoxin group.After the models were made,plasma ET and
CGRP of all the rats were tested by radioimmunoassay method and then the hearts、 lungs and livers of all killed rats were weighed.Results: ① ET and CGRP: Compared with the model group,the high、 low dosage of Baoxin mixture and digoxin group could decrease ET and CGRP level significantly(P<0.01).② Weight of heart、 lung and liver: High dosage of Baoxin mixture and digoxin could decrease the weight of heart,lung and liver significantly(P<0.01).There was no obvious difference between the low dosage of Baoxin mixture group and the model group(P>0.05).Conclusion: Baoxin mixture can regulate and control the neuroendocrine system in rats with chronic heart failure.It has a positive value of treatment.
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