ObjectiveTo study the damaging effect of
trichloroethylene,a organic solvent,on skin and the
protective effect of vitamin
E on it.MethodBALB/c mice were randomly divided into several groups which were exposed to different concentrations of
trichloroethylene,such as 100%TCE group,80%TCE group,40%TCE group,20%TCE group,10%TCE group,solvent(olive oil) control group,positive control(SLS) group,5%VitE treated group,10%VitE treated group,20%VitE treated group and control group.The skin on the back of BALB/c micewere exposed to TCE for one day,observing the damage of the skins and detecting the level of MDA and activity of SOD in skin with kits.ResultThe MDA contents in TCE-exposed groups were gradually rose with the concentrations of TCE,the SOD activities were dropped;while the MDA levels and SOD activities in vitamine E treated groups were gradually declined and rose respectively with the increase of VitE concentration.ConclusionTrichloroethylene may induce skin damage through its oxidation stress effect and vitamin E shows some
protective effect on skin because of its antioxidative effect.