Objective:To observe the effect of Congnao decoction on acetylcholinesterase (AChE) activity of model rats with Alzheimer's
disease. Methods:60 male SD rats were randomized into normal group, sham operation control group, model group, Congnao decoction treatment group 1 (lower dosage), group 2 (medium dosage) and group 3 (high dosage ). Basal forebrain-injured rat was used as model of
Alzheimer's disease, water maze was applied in six groups. The activity of AchE in brain was detected. Results:Compared with normal group and sham operation control group, the swimming time and the error number of model group were obviously increased, the level of AchE in brain was also increased significantly. The swimming time and error number of three treatment groups were shortened, the levels of AchE in brain were decreased compared with model group. Conclusion:Congnao decoction could improve the ability of
learning and memory, decrease cerebral AchE activity of model rat, exerting a positive effect on treatment of cognitive dysfunction.