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Shvoong Home>Medicine & Health>Influence of Peroxy Bond′s Stability of Artemisinin in the Presence of Glutathione and Surfactant Review

Influence of Peroxy Bond′s Stability of Artemisinin in the Presence of Glutathione and Surfactant

Article Review   by:TsingHua     Original Author: Chinese Journal of Analytical Chemistry
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The characteristic endoperoxide bridge in the artemisinin plays an important role in the antimalarial action. The cyclic voltammetric experiments were used to study the influence of peroxy bond′s stability in artemisinin in the presence of glutathione (GSH) and surfactant. The cyclic voltammetry experiments indicated that when the concentration of artemisinin was 1.0×10~ -3 mol/L, C_ GSH ≥2.0×10~ -5 mol/L, adding the cationic surfactant dodecyl dimethyl benzylamine (DBDAB, 1.0×10~ -5 mol/L), the tri-adduct of Glutathione-artemisinin-DBDAB were formed in the ternary system. This tri-adduct reduced at the potential of -0.88 V and its potential shifted 240 mV toward the negative direction compared with that of the free artemisinin. The activation energy is 46.3 kJ/moL higher than that of free artemisinin. So the peroxy bond of artemisinin is more steady. But the anionic surfactant couldn′t form the tri-adducts with artermisinin and glutathione. The mechanisms of the tri-adducts formed at the surface of the electrode were discussed.
Published: March 25, 2006   
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