Objective:To study the mechanism of Naolisu(NLS) capsule for rats' Vascular cognitive impairment(VCI).Methods: Vascular cognitive
impairment model was established by a 2-vessel occlusion(2-OV) method.These model rats were randomly classified into six groups,namely,model group(MDG)、Hydergin group(HDG)、
Naolisu Capsule high-dose group(NLS1)、Naolisu Capsule middle-dose group(NLS2)、Naolisu Capsule low-dose group(NLS3) and sham operation group(SOG).The learning and memory
abilities of rats were estimated by water maze test.The pathomorphologic changes of cerebral cortex neurons have been observed.Results: The learning and memory abilities of rats in NLS1 and NLS2、HDG significantly promoted.The mumber and dimension were upgrade in the cerebral cortex neurons of NLS1 and NLS2、HDG.Conclusion:NLS capsule could enhance the learning and memory abilities of vascular cognitive impairment.The mechanism of NLS capsule including:regulate brain blood infusion and anti-ischemia,inhibiting neuron apotosis,stimulating neurons reproduction.