Objective To observe the action of activating blood circulation to removing stasis rhizome drynaria(AFRD) and its influence on microcitculation and osteoporosis in rats.Methods Adrenaline was injected to the rats to establish the model of !microcirculation disturbance" and retinoic acid was given to obtain the osteoporotic rat model.Blood rheology indexa were detected including viscosity,erythrocyte and platelet aggregation and microcirculation of the bowels.The bone mineral density(BMD) was measured also.Results Reduction of blood viscosity and inhibition of platelet aggregation was shown after AFRD was given,which was significantly different from the control(P<0^01).The spasm of micro artery in rats induced by adrenaline and slowed blood flow was inhibited by AFRD.The BMD and serum level of calcium were increased.Conclusions AFRD is effective in prevatoing the occureuce of microcirculation disorder induced by adrenaline and can increase the BMD and the concentration of serum calcium in rats.