Objective To investigate the
pharmacokinetics of
clindamycin phosphate vagina gel in healthy Chinese female volunteers. Methods
Ten healthy Chinese female volunteers were vaginally given with 5.0g of
clindamycin phosphate vagina gel(the equivalent to 100 mg of clindamycin) once for single dose treatment, and 5.0g,once a day for 3 days, for multiple dose treatment. The serum samples were determinded by HPLC-MS method. The pharmacokinetic parameters of clidamycin were calculated by DAS software. Results The main
pharmacokinetics parameters of clindamycin for single dose and multiple doses were as follow:t_ 1/2 were(15.30±2.62)and(14.78±2.49) h,t_ max were(4.88±0.94)and( 4.70 ±0.59) h, C_ max were(38.30±22.77)and(44.87±26.71) ng·mL~ -1 ,AUC_ 0-∞ were (783.45±351.19) and (1015.68±456.95) ng·h·mL~ -1 ,respectively. Conclusion The C_ max of clindamycin phosphate vagina gel after a single dose and multiple doses were obviously lower and t_ 1/2 were longer than that of clindamycin phosphate oral preparations,which suggests that clindamycin phosphate vagina gel act topically and be Absorbed slowly with systemic actions.