Objective:Investigate
Danzhijiangtang Capsule's effect on serum adiponectin level in
insulin resistance(IR) rats induced
by low dose of streptozotocin(STZ) and high calorie food to find out its functional target.Methods:Male Wistar rats were randomly divided into normal group、model group、low dose of
Danzhijiangtang Capsule treating group and high dose of Danzhijiangtang Capsule treating group.The rats of normal group were fed with common food while the others with high calorie food and injected with low dose of STZ.The weight、fasting blood glucose(FBG) 、fasting insulin(FIns)、blood fat、adiponectin level of all rats were measured,and insulin sensitivity index(ISI) was calculated accordingly.Results:Danzhijiangtang Capsule could reduce body weight of IR rats.According to the results of biochemical indicator detection,Danzhijiangtang Capsule could reduce FBG level and FIns level,improve blood fat condition,enhance ISI and serum adiponectin level effectively(P<0.05).Conclusion:Danzhijiangtang Capsule can ameliorate IR condition of the model rats and its mechanism is probably related to its effect of enhancing serum adiponectin secreting.