Objective: To observe the effect of
Yifu-juanbi granule on the Caspase-3 in the synovial tissue of
adjuvant arthritis rats
and study the molecular mechanism of
Yifu-juanbi granule which cures rheumatoid arthritis.Methods: After sampled with computer video system,Biomias computer image processing and analyzing software was used to analyze the signal intensity of synovial tissue of
adjuvant arthritis rats.The positive chromosome area and integral light density value of Caspase-3 were gained.Results: Caspase-3 in the synovial tissue of the adjuvant arthritis model rats obviously increased higher than that of the natural rats(P<0.05) while Caspase-3 in the synovial tissue of the positive group and the three groups with Yifu-Juanbi granule large,medium and low dosage obviously increased higher than that of the natural rats(P<0.01).Conclusion: Yifu-Juanbi granule can make Caspase-3 of apoptotic reaction increase the expression intensity in the synovial tissue.The promotion of cell apoposis is one of important part of curing rheumatoid arthritis.