OBJECTIVE To study the effects of
caffeine on
improving the working memory and its
mechanism.METHODS After administrations of the different doses of caffeine,
N-6-cyclopentyladenosine(CPA) and
5-N-(Cycloprodyl)-Carboxmidoadenosine(CPCA),the ability of learning and memory in
rats was tested by
three-panel runway and water maze.RESULTS In three-panel runway and water maze,caffeine decreased the numbers of the errors,and latent period was shortened obviously in water maze.The dose of 8 and 16 mg·kg~(-1)had very significant effect compared with control group.After CPA 0.3 mg·kg~(-1)(ip) and caffeine 8 mg·kg~(-1)(po) were administrated at the same time,the effect of caffeine on the working memory in rats was blocked by CPA.While CPCA and caffeine were used at the same dose,the effect of caffeine was unaffected.CONCLUSION The mechanism of caffeine improving the working memory in rats is related to blocking the adenosine A1 receptors of nerve centre and increasing the release of acetycholine in the nerve center.
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