Objective To study the relationship between hepatic fibrosis and osteoporosis, and to observe the effects of Danshen on preventing bone loss Methods Forty PCR mice were randomly divided into 4 groups. Mice in the control group were treated by daily oral gavage with vehicle. Mice in other three groups were given subcutaneous injection of 40% CCl_4 10ml·kg~ -1 and treated by either daily oral gavage with vehicle, or colchicine, or Danshen for 42 d. The liver injury indexes were measured and the mineral elements and Hydroxyproline of the femur were determined. Results Compared with in control group, the indexes showed typical liver cirrhosis in model group. On the other hand, the dried weight of the femur, the content of bone Hydroxyproline and calcium were markedly reduced in model group. However, content of Calcium and Hydroxyproline were effectively increased in Danshen group. Conclusion The bone mass was lost in mice with chronic hepatic injury induced by CCl_4 and Danshen showed protection of liver tissue and preventive effect on bone loss in such mice.