Aim: To investigate the effect of
tongmaijiangtangbaoshen capsule on the experimental diabetic rats. Methods: Rats were randomly
divided into normal group, model group, and experimental groups (treated by
tongmaijiangtangbaoshen capsule), STZ or alloxan was given to the two latter groups by a single ip to establish diabetic models, the morphological change of glomeruli were checked through microscopy. Blood glucose, cholesterol, creatinine,urine protein and platelet aggregation were analyzed with chemical methods. Results: Tongmaijiangtangbaoshen capsule markedly reduced the level of blood glucose, cholesterol, creatinine and urine protein of diabetic rats, which increased significantly in the experimental model, significantly restrained platelet aggregation. Conclusion: The results suggest that tongmaijiangtangbaoshen capsule may be used to therapy
diabetic nephropathy by reducing the level of blood glucose、 improving glomerular structure and function 、regulating adipose metabolize disorder.