OBJECTIVE To investigate the effects of Soybean isoflavone tablets(SIT) on the normal mice growth and immune
function.METHODS
The normal mice were orally administered by SIT at low dose(0.5 g·kg~(-1)·d~(-1)) and high dose(1.5 g·kg~(-1)·d~(-1)) for 21 days.Weight and mean augmented weight of the mouse were observed once a week.On the 21st day,Phagocytosis of RES,T lymphocyte proliferation and the natural killer(NK) cell
activity were detected.RESULTS SIT at two doses enhanced significantly the T lymphocyte proliferation and the natural killer(NK) cell activity(P<0.05).The mice weights,mean augmented weights,phagocytic rate and phagocytic index from low and high-dose groups were higher than the control group.But the statistically significant differences were not found(P>0.05).CONCLUSION These suggests that SIT has a dose-dependent effect to promote the cellular immunity and NK cell activity,but the mice growth and nonspecific immune
function are not significantly elevated in neither low nor high-dose groups.