Objective:To explore the effect of total flavonoids in Scutellaria baicalensis Georgi on anti-oxidation and anti-inflammation.Methods:Observe the macrophage phagocytic function in the experiment of peritoneal macrophage(PM)phagocytizing chicken red blood cell;research on the effect on FMLP induced mice PM respiratory burst and the effect on LPS induced PM synthesizing COX-2 enzyme in mice.Results:The total flavonoids group of 100mg/kg、200mg/kg dosage could extreme obviously decrease the phagocytic percentage and phagocytic index of mice peritoneal macrophage.The total flavonoids group of 1μg/ml、10μg/ml、100μg/ml dosage could all extreme obviously decrease the peak value of respiratory burst, and the depression rate increases with the dosage.The total flavonoids 100μg/mL group could extreme obviously decrease the PGE2 while the 1μg/ml、10μg/ml dosage group could decrease PGE2 without statistic significance.Conclusion:The total flavonoids has the function of depression on mice peritoneal macrophage phagocytize、respiratory burst and COX-2 synthesize,which could be the basis of its anti-inflammation and depression future research.