AIM:To evaluate pharmacodynamic effects of the extract of
compound Chinese holly leaf administrated by
aerosol inhalation. METHODS:The rats were randomized into normal control group,positive control group,high
dose gastric ravage group (2.79 g· kg-1),middle dose gastric ravage group (1.86 g·kg-1), low dose gastric ravage group (0.93 g·kg-1), high dose aerosol
inhalation group (2.79 g·kg-1),middle dose aerosol inhalation group (1.86 g·kg-1) and low dose aerosol inhalation group(0.93 g·kg-1).The protective effects against the infection of Streptococcus pneumoniae were observed by
phenol red secretion test and antibacterial test in vivo. RESULTS: Compare with normal control group ((0.043 ± 0.009) mg·L-1) ,the phenol red secretion increased significantly (P < 0.05)in high dose gastric ravage group ((0.052 ± 0.009) mg·L-1) ,high dose aerosol inhalation group ((0.055 ± 0.009) mg·L-1) and middle dose aerosol inhalation group ((0.052 ± 0.009) mg·L-1). The mortality decreased significantly(P < 0.05)in aerosol inhalation group(40 % ,40 % ,45 % after 72 h and 40 %, 50 %,55 % after 1 wk respectively)and high dose gastric ravage group(55 % after 72 h and 60 % after 1 wk). CONCLUSION: Aerosol inhalation can improve the therapeutic effect of the compound Chinese holly leaf.
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